The effect of 5% phenytoin solution in improving androgenic hair loss

Formulation, physicochemical characterization and single-group phase II clinical trial with comparison before and after treatment to evaluate the efficacy and clinical safety of 5% phenytoin solution in improving androgenic hair loss

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190901044666N3

Enrollment

Registered

2022-12-17

Start date

2023-01-21

Completion date

Unknown

Last updated

2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Androgenic alopecia. Androgenic alopecia

Interventions

Intervention group: treatment with 5% phenytoin solution twice a day for 4 months. For this purpose, the patient uses one milliliter of 5% phenytoin solution topically on his scalp..

Eligibility

Sex/Gender

Male

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: A man aged between 18 and 50 years Hair loss pattern based on Hamilton Norwood scale (II, III, IV) Sign the consent form Enjoying general health

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
The number of hairs in a specified area of the scalp. Timepoint: At screening, 2 and 4 months after treatment. Method of measurement: ????? ??? ?? ?? ?????? ??? ? ????? ???????In this examination, the area of the scalp is determined, and all examinations are performed on that area. The number of hairs at the beginning of the study, 2 months later and 4 months later is counted by the FotoFinder Tricoscale device. The tricoscale program from the FotoFinder device, a new program for documenting and quantifying hair loss, with the help of this software, all the basic parameters of hair growth and loss are calculated automatically. The parameters measured by this device are: calculating the number and density of hairs, the ratio and frequency of anagen and telogen hairs, the number and density of vulus and terminal hairs, determining hair thickness (optional), determining the number of follicular units. At the same time, the condition of the entire head hair is checked by a precision camera at the beginning of the study, 2 and 4 months after the treatment.	—

Measure

Time frame

The number of hairs in a specified area of the scalp. Timepoint: At screening, 2 and 4 months after treatment. Method of measurement: ????? ??? ?? ?? ?????? ??? ? ????? ???????In this examination, the area of the scalp is determined, and all examinations are performed on that area. The number of hairs at the beginning of the study, 2 months later and 4 months later is counted by the FotoFinder Tricoscale device. The tricoscale program from the FotoFinder device, a new program for documenting and quantifying hair loss, with the help of this software, all the basic parameters of hair growth and loss are calculated automatically. The parameters measured by this device are: calculating the number and density of hairs, the ratio and frequency of anagen and telogen hairs, the number and density of vulus and terminal hairs, determining hair thickness (optional), determining the number of follicular units. At the same time, the condition of the entire head hair is checked by a precision camera at the beginning of the study, 2 and 4 months after the treatment.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfsaneh Sadeghzadeh bazargan

Iran University of Medical Sciences

sadeghzadeh.a@iums.ac.ir+98 21 6435 2421

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026