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Comparing the effects of symbiotic therapy with clomiphene in male infertility with idiopathic oligoastenospermia: a randomized clinical trial

Comparing the effects of symbiotic therapy with clomiphene in male infertility with idiopathic oligoastenospermia: a randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190831044653N3
Enrollment
60
Registered
2020-01-26
Start date
2019-12-22
Completion date
Unknown
Last updated
2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

male infertility with idiopathic oligoastenospermia. Male infertility

Interventions

Intervention 1: Intervention group: one capsule of Familact available in Iranian Pharmaceutical Market, orally. Intervention 2: Control group: one capsule contain of clomiphene available in Iranian Ph

Sponsors

Bojnourd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: sperm concentration in semen <15000000 per cc Percentage of progressive motile spermatozoa < 32% Total motility <40% Total ejaculated spermatozoa<39*106 Normal level of FSH, LH, Prolactin, and free testosterone in serum

Exclusion criteria

Exclusion criteria: Smoking or alcoholic consumption White blood cells in semen >10 6 Chances of being treated with gonadotropins, anabolic steroids, cancer chemotherapy, NSAIDs Have been treated with infertility medications since two months ago Unwillingness to cooperate during treatment A medical history of chemotherapy or radiotherapy for cancer management A history of X ray radiation exposure since 8 months ago Y chromosome microdeletion Karyotype alterations Testicular atrophy and lack of testicular descending Other secondary causes of infertility History of liver dysfunction and sensitivity to clomiphene Medical history of infertility therapy since 2 months ago Ejaculated volume <1.5 ml Percentage of typical forms<4% abnormal level of FSH, LH, prolactin and free testosterone in serum

Design outcomes

Primary

MeasureTime frame
Sperm concentration in semen. Timepoint: end of study. Method of measurement: Sperm count in semen is calculated using sperm concentration. Sperm concentration refers to the number of sperm per unit volume of semen.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbdollah Razi

Bojnourd University of Medical Sciences

abdolahrazi@gmail.com+98 21 3229 7182

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026