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Effect of Probiotic in reducing urticaria and pruritus in people with chronic urticaria

Comparison of the effectiveness of probiotic and antihistamine therapy with antihistamine therapy alone in reducing the number of urticaria and pruritus in chronic urticaria patients

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190825044613N1
Enrollment
42
Registered
2019-12-15
Start date
2019-10-23
Completion date
Unknown
Last updated
2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hives. Urticaria, unspecified

Interventions

Intervention 1: Intervention group: For the first group of patients, treatment includes only antihistamines.Two antihistamines is given twice daily and the type of them is prescribed based on the pati

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: For at least two days of week patients must have urticaria lesions and these lesions must remain for at least 6 weeks. Age between 18 to 45 years old

Exclusion criteria

Exclusion criteria: Serious comorbidities (such as malignancies, mental illness, hepatitis, endocrine or other acute and chronic systemic diseases) Taking any drug other than antihistamines Patients with vasculitis Patients with urticaria due to autoimmune diseases A history of severe gastrointestinal diseases such as indigestion and malabsorption Patients taking corticosterone for any reason A history of asthma and allergies in the patients and their first degree relatives Patients with severe mental problems

Design outcomes

Primary

MeasureTime frame
Itching severity. Timepoint: first visit - 8 Week after treatment. Method of measurement: Questionnaire and visit.;Urticaria activity score over 7 days (UAS7). Timepoint: first visit -- 8 Week after treatment. Method of measurement: Questionnaire and visit.;Number of hives. Timepoint: first visit - 8 Week after treatment. Method of measurement: Questionnaire and visit.

Secondary

MeasureTime frame
Quality of Life. Timepoint: first visit snd 8 Week after treatment. Method of measurement: dermatology Quality Life Index.;Complications. Timepoint: 8 Week after treatment. Method of measurement: interview.;Tolerance of treatment and satisfaction. Timepoint: 8 Week after treatment. Method of measurement: interview.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShokoufeh Sharifi

Iran University of Medical Sciences

sharifishokoufeh67@gmail.com+98 912 343 1408

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026