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The effect of paracetamol and metoclopramide on postoperative pain

The effect of paracetamol, metoclopramide and combination of metoclopramide and paracetamol on pain severity after laparoscopic cholecystectomy and comparison with control group

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190825044610N1
Enrollment
100
Registered
2019-09-14
Start date
2017-04-21
Completion date
Unknown
Last updated
2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain.

Interventions

Intervention 1: Intervention group 1: Intravenous injection of 15mg/kg paracetamol in 20 cc normal saline. Intervention 2: Intervention group 2: Intravenous injection of 0.15mg/kg metoclopramide in 20

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients aged 18-65 year referred to Al-Zahra hospital during the year 1396-1397 for elective laparoscopic cholecystectomy and classified as ASA physical status 1 or 2 were included

Exclusion criteria

Exclusion criteria: Pregnancy Addiction to cigarette, opioid and alcohol Weight over 100 kg Chronic pain that lasts more than 6 months Allergy to metoclopramide or acetaminophen Anxiety before surgery Taking any analgesic 24 hours before surgery

Design outcomes

Primary

MeasureTime frame
Severity of postoperative pain. Timepoint: In extubation time,15 minutes, 30 minutes, 60 minutes, 2 hours, 4 hours, 8 hours,16 hours and 24 hours after operation. Method of measurement: Questionnaire according to Visual Analogue Scale.

Secondary

MeasureTime frame
Blood pressure. Timepoint: In extubation time, 15 minutes, 30 minutes, 60 minutes, 2 hours, 4 hours, 8 hours, 16 hours and 24 hours after operation. Method of measurement: Manometer.;Pulse Rate. Timepoint: In extubation time, 15 minutes, 30 minutes, 60 minutes, 2 hours, 4 hours, 8 hours, 16 hours and 24 hours after operation. Method of measurement: Pulseoxymeter.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Haji Gholam Saryazdi

Esfahan University of Medical Sciences

Haji@med.mui.ac.ir+98 31 3673 0416

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026