The effectiveness of mouthwash that contains amorphous calcium phosphate nanoparticles in a chitosan therapy on tooth decay.

A clinical trial to compare the effectiveness of mouthwash that contains amorphous calcium phosphate nanoparticles in a chitosan with chlorhexidine and fluoride mouthwash in patients undergoing fixed orthodontic treatment.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190821044572N1

Enrollment

Registered

2019-09-06

Start date

2019-09-23

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fixed orthodontic. Fitting and adjustment of orthodontic device

Interventions

Intervention 1: Intervention group: Intervention Group I will receive mouthwash that contains amorphous calcium phosphate nanoparticles in a chitosan daily for two weeks. Intervention 2: Intervention

Eligibility

Sex/Gender

All

Age

14 Years to 18 Years

Inclusion criteria

Inclusion criteria: Undergoing fixed orthodontic treatment Age range of 14-18 years

Exclusion criteria

Exclusion criteria: History or presence of periodontal disease History of allergies

Design outcomes

Primary

Measure	Time frame
Gingival index. Timepoint: Before and 4 weeks after the intervention. Method of measurement: Base on Silness-Löe plaque index.;Plaque index. Timepoint: Before and 4 weeks after the intervention. Method of measurement: Base on Silness-Löe plaque index.;Gingival bleeding index. Timepoint: Before and 4 weeks after the intervention. Method of measurement: Base on Silness-Löe plaque index.	—

Secondary

Measure	Time frame
Streptococcus mutans population. Timepoint: Before and 4 weeks after the intervention. Method of measurement: Based on mineral trioxide aggregate (MTA) method.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Bezhannezhad

Mashhad University of Medical Sciences

Bizhannz921@mums.ac.ir+98 51 3883 2300

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026