Condition 1: Metabolic syndrome. Condition 2: Hyperlipidemia. Condition 3: Overweight and obesity. Condition 4: ????????? ?????. Condition 5: Type 2 diabetes mellitus with hyperglycemia. Metabolic syndrome Mixed hyperlipidemia Overweight and obesity Essential (primary) hypertension Type 2 diabetes mellitus with hyperglycemia
Conditions
Interventions
Intervention 1: Intervention group: Thymus vulgaris extract capsule 500 mg twice aday for 12 weeks which will be donate by Barij essence drug company . Intervention 2: Control group: Placebo capsule (
Sponsors
Bagheiat-allah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: Having at least 3 of the following 5 conditions for diagnosing Metabolic syndrome according to "American Heart Association the National Heart, Lung, and Blood Institute (NHLBI)AHA/NHLBI criteria" including: 1)Elevated fasting glucose: Equal to or greater than 100 mg/dL or use of medication for hyperglycemia 2)Elevated waist circumference: Men – greater than 102 cm and Women – greater than 88 cm 3)Elevated triglycerides: Equal to or greater than 150 mg/dL 4)Reduced HDL cholesterol:Men – Less than 40 mg/dL and Women – Less than 50 mg/dL 5) Elevated blood pressure: Equal to or greater than 130/85 mm Hg or use of medication for hypertension
Exclusion criteria
Exclusion criteria: History of coronary artery disease, previous angioplasty or CABG, congenital heart disease and heart failure Drug history of anti hypertension drugs or other drugs which increase or decrease the blood pressure History of liver disease , hepatitis , cirrhosis, alcohol abuse, using hepatotoxic drugs within 6 months ago Kidney disease (such as CKD , nephrotic and nephritic syndrome , AKI? kidney artery stenosis ) Thyroid dysfunction and using levothyroxine Using anti hyperlipidemic agents Using anti diabetic agents and insulin Pregnancy and lactation Psychiatric disorders which impaired regular drug using History of active cancer or treatment with chemotherapic drugs Hypersensitivity to thyme and its ingredients History of bariatrics surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic and Diastolic arterial pressure. Timepoint: Beginning of study and then 12 weeks later. Method of measurement: With a "Calibrated handheld pressure gauge".;Serum Fasting Blood Glucose. Timepoint: Beginning of study and then 12 weeks later. Method of measurement: Laboratory measurement of Serum sample Fasting blood glucose.;Waist circumference. Timepoint: Beginning of study and then 12 weeks later. Method of measurement: Measurement of waist circumference using a Tape measure in the level of umbilicus.;Serum Triglyceride level. Timepoint: Beginning of study and then 12 weeks later. Method of measurement: Laboratory measurement of Serum sample Teriglyceride level.;Serum high dense lipoprotein (HDL) level. Timepoint: Beginning of study and then 12 weeks later. Method of measurement: Laboratory measurement of Serum sample High dense lipoprotein (HDL). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamid Babahosseini
Tehran University of Medical Sciences
Outcome results
None listed