Drug-induced Peripheral polyneuropathy. Drug-induced polyneuropathy
Conditions
Interventions
Intervention 1: Intervention group: Receiving 500 mg metformin Po Bid during chemotherapy with Paclitaxel. Intervention 2: Control group: Without receiving additional medications during chemotherapy.
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Non-diabetic patients with histologically confirmed cancer; scheduled to undergo paclitaxel chemotherapy for cancer.
Exclusion criteria
Exclusion criteria: Patients with diabetes mellitus; A history of clinically significant hypersensitivity reaction to medications; Pregnancy; Patients who are currently using metformin; Metformin induced neuropathy at 12 week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prevention of paclitaxel-induced peripheral neuropathy. Timepoint: Before and after intervention (week 12). Method of measurement: Nerve conduction study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: Weekly during intervention course. Method of measurement: Taking a history from the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSamineh Sadeghian
Shiraz University of Medical Sciences
Outcome results
None listed