The effect of zinc supplements on the oxidative stress and reduction of withdrawal symptoms in opioid addicts in the withdrawal syndrome

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190811044513N1

Enrollment

Registered

2019-09-11

Start date

2019-08-22

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

People with Opioid Addiction. Family history of other substance abuse

Interventions

Intervention 1: Intervention group: Opioid addicts who use 30 mg zinc tablets from the US company Naturemade. The pill is given to each patient during one month and one pill for each day. It is recomm

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Opioid use for two years and more Admission within a maximum of one week from the time of withdrawal Not taking medications away from the specialist opinion Absence of acute and chronic inflammatory diseases and any other acute or chronic infections Lack of AIDS, hepatitis and diabetes

Exclusion criteria

Exclusion criteria: Re-consuming by people before sampling Use of drugs that have an effect on inflammation and oxidative stress Getting any disease during research Attempted suicide or a history of it during the past year

Design outcomes

Primary

Measure	Time frame
Oxidative stress factors, reduction of withdrawal symptoms. Timepoint: At the beginning and end of the study. Method of measurement: Serum level measurement by using kits.	—

Secondary

Measure	Time frame
Antioxidant capacity of serum. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Lipid Peroxidation Index. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Thiol groups index. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Enzymatic activity of glutathione peroxidase. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Enzymatic activity of superoxide dismutase. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Evaluation of withdrawal symptoms. Timepoint: At the beginning and end of the study. Method of measurement: COWS questionnaire.	—

Measure

Time frame

Antioxidant capacity of serum. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Lipid Peroxidation Index. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Thiol groups index. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Enzymatic activity of glutathione peroxidase. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Enzymatic activity of superoxide dismutase. Timepoint: At the beginning and end of the study. Method of measurement: Colorimetric method.;Evaluation of withdrawal symptoms. Timepoint: At the beginning and end of the study. Method of measurement: COWS questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Hasanalizadeh

Hamedan University of Medical Sciences

alizadeh01996@gmail.com+98 81 3838 1591

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026