The effect of melatonin on the severity of postoperative pain

Effect of preoperative sub-lingual melatonin on postoperative pain of patients undergoing colorectal surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190811044506N1

Enrollment

Registered

2019-08-31

Start date

2019-09-23

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: postoperative pain. Condition 2: abdominal pain. Complications of procedures, not elsewhere classified Abdominal and pelvic pain

Interventions

Intervention 1: Intervention group: 6 mg melatonin sublingual one hour before surgery. Intervention 2: Control group: 6 mg placebo sublingual one hour before surgery.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: The patient is a candidate for colorectal surgery. ASA Classification of 1 and 2 Give informed, voluntary and written consent Have not used any narcotic drugs before surgery.

Exclusion criteria

Exclusion criteria: a history of alcohol or drug abuse a history of Seizure a history of diabetes

Design outcomes

Primary

Measure	Time frame
Postoperative pain severity. Timepoint: 0, 2, 6, 12 and 24 hours after surgery. Method of measurement: Verbal rating scale.	—

Secondary

Measure	Time frame
Sedation. Timepoint: 6, 12 and 24 hours after surgery. Method of measurement: Ramsay sedation score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Shakiba

Mashhad University of Medical Sciences

shakibam961@mums.ac.ir+98 51 3601 5168

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026