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Evaluation of Levamisole efficacy in treatment of Covid-19

Evaluation of Levamisole efficacy and safety in combination with routine therapy in patients with Covid-19: a clinical trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190810044500N7
Enrollment
50
Registered
2020-09-19
Start date
2020-04-08
Completion date
Unknown
Last updated
2020-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. Coronavirus infection, unspecified

Interventions

Intervention 1: Control group: Routine treatment includes hydroxychloroquine 200 mg twice daily for 5 days with acetaminophen 4 mg used during fever and diphenhydramine syrup 10 cc every 8 hours to co

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Ages 18 to 60 years Diagnosis of Covid-19 over the past 24 hours Female patients are not exposed to pregnancy and do not become pregnant until thirty days later. Not taking levamisole for the past five days (due to 16-hour drug half-life) Patients suspected to covid-19 based on clinical signs and symptoms of CT scan and candidate for outpatient treatment No medication other than protocol No underlying disease

Exclusion criteria

Exclusion criteria: Hospitalized Patients Patients with hemodynamic instability History of cirrhosis, hepatitis and severe liver disease, severe renal failure (less than 30ml / min) Patients currently taking levamisole for other uses such as parasitic infection Patients with a history of allergic reaction or sensitivity to levamisole Patients receiving chemotherapy for cancer Pregnancy and lactation Ages less than 18 years and over 60 years Patients with underlying diseases including diabetes and hypertension

Design outcomes

Secondary

MeasureTime frame
Mortality. Timepoint: after completion of the intervention. Method of measurement: Clinical examination.;Side effects that occur during treatment or severe side effects that lead to discontinuation of treatment. Timepoint: Before the intervention, after completion of the intervention. Method of measurement: Clinical examination.

Primary

MeasureTime frame
Clinical symptoms include fever, cough, shortness of breath. Timepoint: Before the intervention, after completion of the intervention. Method of measurement: Clinical examination.;Patients need to be hospitalized. Timepoint: Before the intervention, after completion of the intervention. Method of measurement: Clinical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirreza Roustaei Firouzabad

Yazd University of Medical Sciences

amirroostaei93@gmail.com+98 35 3820 3419

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 15, 2026