Ventilator-Associated Pneumonia. Unspecified acute lower respiratory infection
Conditions
Interventions
Intervention 1: Intervention group: In the first group, patients will receive one Femilact (Zist-Takhmir Com.) capsule and one placebo tablet (prepared by pharmaceutics laboratory of Yazd Faculty of P
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with head trauma and older than 18 years who have been mechanically ventilated for at least 48 hours Oxygen saturation (O2 saturation) greater than 90% FIO2 less than 50% PEEP less than 8 cm of water Hemodynamic stability during the last 12 hours Body temperature between 36 and 39 degrees
Exclusion criteria
Exclusion criteria: Patients who do not agree to participate in the study Severe immune system defects (acquired or genetic) including patients with active cancer undergoing chemotherapy or active HIV Fever before endotracheal intubation Patients who underwent cardiopulmonary resuscitation after trauma Patients with a history of previous sensitivity to domperidone and probiotic compounds Taking other probiotic drugs Patients with gastrointestinal absorption intolerance Patients with previous tracheostomy or history of mechanical ventilation in the same hospital
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood gases including oxygen pressure, carbon dioxide, saturated oxygen pressure and pH. Timepoint: Before starting the intervention and one day later and after weaning of mechanical ventilation. Method of measurement: blood sample.;Hemoglobin. Timepoint: Before starting the intervention and one day later and after weaning of mechanical ventilation. Method of measurement: blood sample.;Level of consciousness. Timepoint: Before starting the intervention and one day later and after weaning of mechanical ventilation. Method of measurement: glass coma scale.;Sofa score. Timepoint: Before starting the intervention and one day later and after weaning of mechanical ventilation. Method of measurement: Scoring based on pulmonary, coagulation, liver, cardiovascular, central nervous system and kidney status. | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration of weaning. Timepoint: From the start of the process of separation from the device until the patient's spontaneous breathing. Method of measurement: Counting the number of days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Saghafi
Yazd University of Medical Sciences
Outcome results
None listed