Knee osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: Patients will use the topical gel of ketorolac 2% (prepared in the Pharmaceutics Laboratory of Yazd School of Pharmacy) three times daily for 2 weeks. Patients will
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 40 Primary osteoarthritis Pain in more than half of the days of the previous month during one of the following activities: walking, going up and down stairs, standing or lying on a bed or mattress during Night Radiographic evidence of tibiofemoral or patellofemoral osteoarthritis baseline score of 40 on the WOMAC scale no intra-articular injection of hyaluronic acid / glucocorticoid during the last six months no positive pregnancy test or pregnancy program during the study
Exclusion criteria
Exclusion criteria: Not taking the right medicine Serious medical condition in which the patient is unable to return for regular visits History of liver disease Inability to walk without a cane Secondary osteoarthritis for example following trauma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Joint range of motion. Timepoint: At the beginning of the study and 7 and 14 days after starting topical ketorolac and topical diclofenac. Method of measurement: Western ontario and mc master universities osteoarthritis index and Knee Injury and Osteoarthritis Outcome Score. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: At the beginning of the study and 7 and 14 days after starting ketorolac topical and diclofenac. Method of measurement: Western Ontario and mc master universities osteoarthritis index and Visual Analogue Scale and Knee Injury and Osteoarthritis Outcome Score.;Inflammation. Timepoint: At the beginning of the study and 7 and 14 days after starting ketorolac topical and diclofenac. Method of measurement: Western ontario and mc master universities osteoarthritis index and Visual Analogue Scale and Knee Injury and Osteoarthritis Outcome Score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactmehdi rostami
Yazd University of Medical Sciences
Outcome results
None listed