weaning of mechanical ventilation.
Conditions
Interventions
Intervention 1: Intervention group:. Intervention 2: Control group:.
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Mechanical ventilation through endotracheal tube for at least 24 hours oxygen saturation greater than 90% FIO2 less than 50% PEEP less than 8 cm water hemodynamic stability over the past 12 hours sedation withdrawal or sedation reduction Over the past 48 hours neurological status stabilized with Ramsay's score less than 5 temperature between 36 and 39 degrees
Exclusion criteria
Exclusion criteria: Pregnancy or lactation under 18 years of age tracheostomy hepatic encephalopathy cerebral edema acute hydrocephalus myasthenia gravis Acute polyneuropathy lack of decision to discontinue respiratory support prolonged cardiac arrest with poor neurologic prognosis coincident extubation with day one acute right ventricular failure renal failure plasma urea exceeding (25 mol / L), Plasma creatinine greater than (180 mol / min) or creatinine clearance less than 30 ml / min, or more than 25% increase in creatinine over the past 24 hours contrast injection over the past six hours Serum sodium level greater than (150 m Eq) / L serum potassium level less than 3.5 (m Eq) / L metabolic alkalosis with arterial pH greater than 7.5 need for sedation or unconsciousness concurrent administration of drugs Potential respiratory stimulants such as doxapram and medroxyprogesterone hypothyroidism Known allergy to donepezil or medroxy progesterone
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood gas includes PO2, PCO2, PHCO3, O2 saturation and PH. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: blood sample.;Hemoglobin. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: blood sample.;Level of consciousness. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: glass coma scale.;Sofa score. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: Scoring based on pulmonary, coagulation, hepatic, cardiovascular, central nervous system and renal status. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of weaning. Timepoint: From the process of separation from the device to the patient's spontaneous breathing. Method of measurement: Counting the number of days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Saghafi
Yazd University of Medical Sciences
Outcome results
None listed