Radiodermatitis. Malignant neoplasm of breast
Conditions
Interventions
Intervention 1: Intervention group:Topical 0.5% timolol gel is made by the operator in the laboratory. Patients with breast cancer referred to the center Radiation therapy is included in the study. Pa
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients older than 18 years with positive histology confirm invasive and localized breast cancer, who are candidates for adjuvant radiotherapy after surgery (breast conserving or mastectomy). Adequate literacy to fill out a consent form, understand the study, use the drug, report pain and possible side effects
Exclusion criteria
Exclusion criteria: Inflammatory or metastatic carcinoma Extensive skin diseases Connective tissue diseases known sensitivity to beta-antagonist drugs
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life. Timepoint: Before and after intervention. Method of measurement: According to the questionnaire EORTC QLQ-C30 (version 3).;When the complication occurs. Timepoint: From the beginning of the intervention to two weeks after the end of radiotherapy. Method of measurement: Based on the doctor's observation and the person's statements. | — |
Primary
| Measure | Time frame |
|---|---|
| Acute Radiation Dermatitis. Timepoint: Weekly during radiotherapy and two weeks after the end of radiotherapy. Method of measurement: Based on the Radiation Therapy Oncology Group and the European Organization for Research and Treatment of Cancer (RTOG / EORTC).;Moist desquamation. Timepoint: Weekly during radiotherapy and two weeks after the end of radiotherapy. Method of measurement: Based on the Common Terminology Criteria for Adverse Events (CTCAE, version 5.0).;The worst pain experienced. Timepoint: once every two weeks. Method of measurement: Based on Dermatology Life Quality Index (DLQI).;Patient' skin phototype. Timepoint: Before starting radiotherapy. Method of measurement: Based on the Fitzpatrick skin phototype scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactzahra hakimi
Yazd University of Medical Sciences
Outcome results
None listed