"The Effect of Guar Gum Gel Containing Licorice Root Extract in Grade II Burns"

Preparation & Evaluation of Healing Effect of Topical Gel of Guar Gum Containing Hydro-Alcoholic Extract of Licorice Root (Glycyrrhiza glabra) in Grade II Burn Patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190810044500N10

Enrollment

Registered

2021-02-09

Start date

2021-01-20

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burn. Burn of second degree of trunk, unspecified site

Interventions

Intervention 1: Intervention group: Patients will be treated daily with topical guar gum gel containing licorice root extract for three weeks delivered from a thin layer of the contents of the drug. I

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Presenting to the burn center in the first 24 hours after the burn Having grade II burns, superficial and deep, that involve less than 10% of the body's surface area No comorbidity that delays the repair process (such as diabetes, chronic kidney disease, malignancy, and chronic use of corticosteroids) Absence of respiratory burns as well as chemicals or electric burn No burns on the face and perineum

Exclusion criteria

Exclusion criteria: Concurrent infection during the study Lack of response to treatment The need for skin graft surgery

Design outcomes

Primary

Measure	Time frame
Mean time of wound healing. Timepoint: The wound healing process is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment on the wound area. Method of measurement: Clinical examination.;The severity of vascularity. Timepoint: The severity of vascularity is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of thickness. Timepoint: The rate of thickness is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of flexibility. Timepoint: The rate of flexibility is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of pigmentation. Timepoint: The rate of pigmentation is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of pain. Timepoint: The rate of pain is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of pruritus. Timepoint: The rate of pruritus is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.	—

Measure

Time frame

Mean time of wound healing. Timepoint: The wound healing process is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment on the wound area. Method of measurement: Clinical examination.;The severity of vascularity. Timepoint: The severity of vascularity is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of thickness. Timepoint: The rate of thickness is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of flexibility. Timepoint: The rate of flexibility is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of pigmentation. Timepoint: The rate of pigmentation is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of pain. Timepoint: The rate of pain is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.;The rate of pruritus. Timepoint: The rate of pruritus is measured during the study period on days 1, 3, 7, 10, 14, and 21 after starting to use Licorice gel and Silver Sulfadiazine ointment in the wound area. Method of measurement: Clinical examination.

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Secondary

Measure	Time frame
Life quality. Timepoint: End of the study. Method of measurement: According to "Quality of Life Questionnaire (QLQ-C30) version 3" of European Organization for Research and Treatment of Cancer (EORTC).;Complications observed. Timepoint: End of the study. Method of measurement: Based on the doctor's observation and the person's statements.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Saghafi

Yazd University of Medical Sciences

F.saghafi@ssu.ac.ir+98 35 3820 3419

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026