Chronic kidney disease. Chronic kidney disease, stage 5
Conditions
Interventions
Intervention 1: Intervention group: The zinc-supplementation group(n=20) will receive a 220-mg zinc sulfate capsule(containing 50 mg zinc) manufactured by Alhavi Pharmaceutical Company (Tehran, Iran
for 8 weeks. Intervention 2: Control group:The control-group(n=20) will receive a placebo capsule(220-mg corn starch), for 8 weeks.
Sponsors
Zahedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 70 Years
Inclusion criteria
Inclusion criteria: Diabetic hemodialysis patients(Pass at least 6 months from hemodialysis); Age:15-70; Not having inflammatory diseases affecting on serum inflammatory markers; One month before the study began no supplements containing antioxidants,zinc supplement,vitamins E and C supplements; Steroid and non-steroidal anti-inflammatory drugs should not be used.
Exclusion criteria
Exclusion criteria: If the patients have been taking antibiotics for the past month and with infectious or feverish disease. Also Diseases affecting serum copeptin like severe cardiovascular disease, Hypothyroidism ,hyperthyroidism and sepsis are not included in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum copeptin. Timepoint: Before and after 8-week intervention. Method of measurement: It measured by ELISA method with standard kit.;Serum insulin. Timepoint: Before and after 8-week intervention. Method of measurement: It measured by ELISA method with standard kit.;C-Reactive-Protein. Timepoint: Before and after 8-week intervention. Method of measurement: It measured by ELISA method with standard kit.;Nutritional status. Timepoint: Before and after 8-week intervention. Method of measurement: Food Frequency Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin resistance. Timepoint: Before and after 8-week intervention. Method of measurement: Homeostasis model assessment measuring insulin resistance. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRazieh Hosseini
Zahedan University of Medical Sciences
Outcome results
None listed