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Comparing neostigmine and metoclopramide on gastric residual volume

Comparing the effect of intravenous neostigmine and metoclopramide on gastric residual volume of mechanically ventilated intensive care unit patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190804044432N1
Enrollment
100
Registered
2019-08-18
Start date
2019-09-08
Completion date
Unknown
Last updated
2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dilatation of volume. Acute dilatation of stomach

Interventions

Intervention 1: Intervention group: In the first group, neostigmine, manufactured by Caspian Tamin Pharmaceutical Company, was used at 2.5 mg / 100 ml of normal saline, intravenously and one time. Int

Sponsors

Zahedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age between 20 and 50 years Patients under mechanical ventilation Patients with enteral nutrition through nasogastric tube

Exclusion criteria

Exclusion criteria: Previous use of beta blockers Heart Block Bradycardia (heart rate less than 60) before inclusion Hypothermia in the form of central temperature below 35 degrees Kidney Failure (CR> 1.5) Use Erythromycin or Cisapride within 8 hours before starting the study Recent surgery on stomach or digestive tract within the last ten days Signs and symptoms of bowel obstruction Pregnancy and lactation Active bronchospasm Extrapyramidal symptoms Sensitivity to Neostigmine Active gastrointestinal bleeding

Design outcomes

Primary

MeasureTime frame
Gastric residual volume. Timepoint: Before starting the drug infusion and 3, 6, 9 and 12 hours after the start of the infusion. Method of measurement: Aspirate with a gavage syringe.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSara Saneie Moqadam

Zahedan University of Medical Sciences

m_Shahrakim@zaums.ac.ir+98 54 3329 5725

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026