Migraine Headache. Migraine
Conditions
Interventions
Intervention 1: Intervention group: In the first week, all patients will receive lacosamide 100 mg twice a day, and from the second week, they will also receive 150 mg every 12 hours, and in the third
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adults over 18 years old migraine (with or without aura) moderate to high intensity migraine headache (VAS=4)
Exclusion criteria
Exclusion criteria: Severe depression or suicidal thoughts Thyroid disorders Pregnancy Lactation History of ischemic cerebral disease or ischemic heart disease Renal dysfunction (GFR less than 30 ml/min) medication overuse headache History of drug abuse and alcohol History of hepatic failure A history of cardiac arrhythmia or using drugs that affect heart rhythm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of days that the individual has experienced headache. Timepoint: At the beginning of the study, in the 8th week (56 days after baseline) and in the 11th week (84 days after baseline). Method of measurement: History taking.;The number of headache attacks. Timepoint: weekly, up to 12 weeks. Method of measurement: Visual analogue scale (VAS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Disability improvement. Timepoint: Baseline and third month. Method of measurement: Migraine Disability Assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMonireh Ghazaeian
Mazandaran University of Medical Sciences
Outcome results
None listed