Multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group: dalfampridine 10 m q12 hour for 8 weeks. Intervention 2: Control group: Amantadine 100 mg q 12 hour for 8 weeks.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients were aged more than 18 years Patients with multiple sclerosis according to Mcdonald criteria 2017 and EDSS less than 5.5 MS patients with at least fatigue score of 33 according to MFIS
Exclusion criteria
Exclusion criteria: Severe depression Hypothyroidism Severe anemia ( Hb‹ 9 g/dl) Pregnancy or breast feeding Ischemic heart disease or cardiovascular disease Renal insufficiency MS exacerbation within 30 days before Uncontrolled blood pressure (BP more than 160/100 mm Hg) use of other effective treatment on fatigue Alcohol, recreational and substance abuse history Monoamine oxidase inhibitors (MAOIs) use Narcolepsy history Psychosis history Seizure history
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatigue improvement. Timepoint: At weeks 4, and 8. Method of measurement: MFIS questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: At weeks 4 , 8. Method of measurement: SF-36 Questionnaire.;Tolerable of therapeutic regimen. Timepoint: Weekly. Method of measurement: History taking. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMonireh Ghazaeian
Mazandaran University of Medical Sciences
Outcome results
None listed