Skip to content

Investigating the effects of olanzapine on the anxiety of children with cancer

Olanzapine effects on chemotherapy regimen induced anxiety in pediatric patients with cancer: A randomized, double-blind, placebo-controlled clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190804044429N13
Enrollment
60
Registered
2024-09-02
Start date
2024-09-22
Completion date
Unknown
Last updated
2024-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lymphoid leukemia. Lymphoid leukemia

Interventions

Intervention 1: Intervention group: Half of the patients will be randomly assigned to receive olanzapine (children aged 7 to 12 will get a dose of 2.5 mg, and those over 12 will get 5 mg every night)

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
7 Years to 16 Years

Inclusion criteria

Inclusion criteria: Children aged 7 to 16 with a cancer diagnosis who are receiving chemotherapy and have an ASA I-II score Anxiety state score based on Spence scale with 60 points

Exclusion criteria

Exclusion criteria: History of congenital heart disease Intellectual disability, The use of psychiatric medications, History of liver disorders, History of seizures and neurological conflicts following cancer

Design outcomes

Secondary

MeasureTime frame
Reducing anxiety from chemotherapy. Timepoint: During chemotherapy treatment. Method of measurement: Visual analogue scale.;Tolerance level and the occurrence of side effects. Timepoint: Study duration. Method of measurement: History taking.

Primary

MeasureTime frame
Reducing anxiety in children with cancer. Timepoint: During chemotherapy treatment. Method of measurement: Spence Children's Anxiety Scale - Child (SCAS-Child).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMonireh Ghazaeian

Mazandaran University of Medical Sciences

ghazaeianm@gmail.com+98 11 3334 3989

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026