Efficacy of Aloe Vera gel in systolic heart failure

Evaluation the efficacy of “Aloe Vera” oral gel on the quality of life in patients with systolic heart failure : A double blind, randomized controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190803044426N1

Enrollment

Registered

2019-12-25

Start date

2019-12-11

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systolic heart failure. Chronic systolic (congestive) heart failure

Interventions

Intervention 1: Patients will receive Aloe Vera gel capsule two times a day for next 8 weeks.Each capsule contains 150 mg of Aloe Vera gel . The drug will be provided by Shahid Beheshti university pha

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Written informed consent Age: 18 years or above Systolic heart failure disease with reduced left ventricular ejection fraction =40% or Symptomatic chronic heart failure NYHA class II-III. Patients willing to continue their standard continuing heart medications which prescribed by cardiologist Ambulatory systolic heart failure patients in stable condition (no hospitalization during the trial and no planned surgery)

Exclusion criteria

Exclusion criteria: Pregnancy Breast feeding Hypersensitivity to Aloe Vera Chronic Inflammatory disease Collagen vascular disease History of peptic ulcer Acute infectious disease Decompensated heart failure Chronic liver disease Chronic renal failure Hemorrhoids Malignancy

Design outcomes

Primary

Measure	Time frame
Quality of Life Score in the Minnesota Questionnaire. Timepoint: Measure the quality of life score at the beginning of study(before intervention)and one week after taking Aloe Vera gel. Method of measurement: Minnesota Living With Heart Failure Questionnaire.	—

Secondary

Measure	Time frame
The distance traveled in six minute walk test. Timepoint: Measure the distance traveled in six minute walk test at the beginning of study (before intervention) and one week after taking the Aloe Vera gel. Method of measurement: Six minute walk test.;Insomnia score in the Insomnia Severity Index (ISI) questionnaire. Timepoint: Measure the insomnia score at the beginning of study (before intervention) and one week after taking intervention (Aloe Vera gel). Method of measurement: The Insomnia Severity Index (ISI) questionnaire.;Quality of sleep score in the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Timepoint: Measure the quality of sleep score at the beginning of study (before intervention) and one week after taking intervention (Aloe Vera gel). Method of measurement: The Pittsburgh Sleep Quality Index (PSQI) questionnaire.;Obstructive sleep apnea score in STOP-BANG sleep apnea questionnaire. Timepoint: Measure the obstructive sleep apnea score at the beginning of study (before intervention) and one week after taking intervention (Aloe Vera gel). Method of measurement: STOP-BANG sleep apnea questionnaire.	—

Measure

Time frame

The distance traveled in six minute walk test. Timepoint: Measure the distance traveled in six minute walk test at the beginning of study (before intervention) and one week after taking the Aloe Vera gel. Method of measurement: Six minute walk test.;Insomnia score in the Insomnia Severity Index (ISI) questionnaire. Timepoint: Measure the insomnia score at the beginning of study (before intervention) and one week after taking intervention (Aloe Vera gel). Method of measurement: The Insomnia Severity Index (ISI) questionnaire.;Quality of sleep score in the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Timepoint: Measure the quality of sleep score at the beginning of study (before intervention) and one week after taking intervention (Aloe Vera gel). Method of measurement: The Pittsburgh Sleep Quality Index (PSQI) questionnaire.;Obstructive sleep apnea score in STOP-BANG sleep apnea questionnaire. Timepoint: Measure the obstructive sleep apnea score at the beginning of study (before intervention) and one week after taking intervention (Aloe Vera gel). Method of measurement: STOP-BANG sleep apnea questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeideh Sabbaghzadegan

Iran University of Medical Sciences

sabbaghzadegan.s@tak.iums.ac.ir+98 21 5558 0388

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026