Effect of Grape seed extract in treatment of fatty liver

Investigating the effect of grape seed extract on blood pressure and some serum antioxidant indices in patients with non-alcoholic fatty liver disease

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190731044392N2

Enrollment

Registered

2022-08-19

Start date

2022-10-27

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non Alcoholic Fatty liver Disease. Fatty (change of) liver, not elsewhere classified

Interventions

Intervention 1: Intervention group: daily consumption of 260 mg grape seed extract supplement by Shari company (twice a day and each time one tablet equal to 2.5 grams) for 60 days orally, with mornin

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: 20-60 years old Patient with non alcoholic fatty liver disease

Exclusion criteria

Exclusion criteria: Patients who have diabetes, cardiovascular, kidney and other hepatic diseases Pregnant or lactating women Smoking Alcohol consumption Use of dietary supplements

Design outcomes

Primary

Measure	Time frame
Weight. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Digital scale.;Body mass index. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Body weight in kilograms divided by height squared in meters.;Quality of life. Timepoint: Before intervention and 2 months after intervention. Method of measurement: SF-36 Questionnaire.;Malondialdehyde. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Blood test.;Catalase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Blood test.;Glutathione Peroxidase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Blood test.;Superoxide dismutase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Blood test.;Waist circumference. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By measuring tape according to meter.;Hip circumference. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By measuring tape according to meter.	—

Measure

Time frame

Weight. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Digital scale.;Body mass index. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Body weight in kilograms divided by height squared in meters.;Quality of life. Timepoint: Before intervention and 2 months after intervention. Method of measurement: SF-36 Questionnaire.;Malondialdehyde. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Blood test.;Catalase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Blood test.;Glutathione Peroxidase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Blood test.;Superoxide dismutase. Timepoint: Before intervention and 2 months after intervention. Method of measurement: Blood test.;Waist circumference. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By measuring tape according to meter.;Hip circumference. Timepoint: Before intervention and 2 months after intervention. Method of measurement: By measuring tape according to meter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Razmi

Ahvaz University of Medical Sciences

hamidrezarazmi95@gmail.com+98 61 3333 3050

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026