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Evaluation of the effect of misoprostol with and without letrozol in missed aborted

Evaluation of the effect of misoprostol with and without letrozole as premedication on induction of abortion in pregnant women with missed abortion at their first trimester of pregnancy

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190730044380N1
Enrollment
126
Registered
2019-11-11
Start date
2016-08-22
Completion date
Unknown
Last updated
2019-12-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Missed abortion. Missed abortion

Interventions

Intervention 1: Intervention group: missed aborted women with geatational age less than 12 weeks- The case group received 10 mg of letrozole daily for three days, then received 800 µg of vaginal misop

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1:Gestational age less than 12 week(confirmed with ultrasonogarphy) patient with missed abortion (confirmed with ultrasonography) acceptance of participant patient age above 18 years old hemoglobin above 12

Exclusion criteria

Exclusion criteria: Clinical manifestation or history of adrenal gland impairment History of any malignancy History or clinical evidence of any thromboembolic impairment History of hepatic or renal diseases Have IUD History of cardiovascular disease that prescription of misoprostol or letrozol forbidden based on cardiologist opinion. History of use corticosteroid Present of classic scar or t shape scar on the uterus Impairment of coagulation test

Design outcomes

Primary

MeasureTime frame
PRESENT OF ABORTION:COMPLETE,in complete. Timepoint: every 12 hours. Method of measurement: ultrasonography.

Secondary

MeasureTime frame
Time interval from induction to abortion. Timepoint: hours. Method of measurement: questionaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Goharian

Esfahan University of Medical Sciences

mrym.gn72@gmail.com+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026