Coronary artery disease. Atherosclerotic heart disease of native coronary artery with angina pectoris
Conditions
Interventions
Intervention 1: Intervention group 1: The first intervention group will receive sodium selenite-enriched yeast capsule at a dose of 200 µg for 8 weeks. Yeast supplement enriched with sodium selenite h
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Willingness to participate in the study and sign informed consent form after full knowledge of the purpose and method of the study Men and women aged 18-18 years old Diagnosis of atherosclerosis by a physician with angiography with at least 50% vascular obstruction in at least one vessel Not taking any antioxidant and anti-inflammatory supplements for at least 1 month before starting the study Overweight and obesity (BMI = 25 - 35 Kg / m²)
Exclusion criteria
Exclusion criteria: Affecting by malignancies, autoimmune and infectious diseases Blood disease Osteoporosis Chronic diseases such as liver, kidney and thyroid diseases Pregnancy Lactation Consuming antacids Consuming antibiotics Consuming alcohol Cigarette smoking Allergies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gene expression of IL-6. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Real-time PCR.;Gene expression of TNF-a. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Real-time PCR.;Gene expression of IL-1ß. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Real-time PCR. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNeda Roshanravan
Tabriz University of Medical Sciences
Outcome results
None listed