Effect of Ephedrine and Ketamine on onset time of Atracurium

Comparison of the effects of Ephedrine and Ketamine with Placebo on onset time of Atracurium in patients under general anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190721044285N1

Enrollment

141

Registered

2019-07-31

Start date

2019-08-06

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intubation. Failed or difficult intubation

Interventions

Intervention 1: First Intervention group: In this group, each patient is given 0.05 mg/kg Ephedrine intravenous before injection of Atracurium. Intervention 2: Intervention group: In this group, each

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with ASA score 1 or 2 Patients undergoing elective surgery 8 hours fasting at least

Exclusion criteria

Exclusion criteria: Patients with BMI between 16.5 to 35 Liver or kidney disease Patients with mallampati test 3 or more Patients with HTN or IHD in one year ago

Design outcomes

Primary

Measure	Time frame
Shorten the onset time of the effect of Atracurium. Timepoint: 2 minutes after the administration of fentanyl until 2 response in Train Of Four at 10 seconds intervals. Method of measurement: Nerve Stimulator ( train of four ).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Ghasemi

Tehran University of Medical Sciences

mhd.ghasemi371@gmail.com+98 28 3333 4646

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026