The comparison of effect of pregabalin and duloxetine on post-op pain

The comparison of peri-operative administration of pregabalin and duloxetine on post-op pain after TKA

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190719044276N1

Enrollment

Registered

2020-02-20

Start date

2019-11-22

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-op pain

Interventions

Intervention 1: First intervention group: the patients who receive a 75 milligram pregabalin tablet 1.5 hours before surgery and 12 and 24 hours after TKA. Intervention 2: Second intervention group: t

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patients have TKA (total knee arthroplasty) surgery Patients have spinal anesthesia Patients are ASA I-II

Exclusion criteria

Exclusion criteria: Patients don't have consent Patients with allergy history of pregabalin and duloxetine Lower limbs neuropathy Drug abuse Therapy with pregabalin or deluxetine Any diseases that hinder patients to cooperate in this research

Design outcomes

Primary

Measure	Time frame
The pain score after total knee arthroplasty surgery. Timepoint: 1,12,24,48 hours after surgery. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarnad Imani

Iran University of Medical Sciences

farimani@iums.ac.ir+98 21 6651 5758

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026