Lichen planopilaris. Lichen planopilaris
Conditions
Interventions
Intervention 1: Intervention group: Methotrexate(15mg/week orally,in one day) will be administered in one group(16 patients) for six months. Intervention 2: Intervention group: Cyclosporine( 300mg/day
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Scalp involvement more than 10% Local disease (<10%Involvement) resistant to 3-month topical treatment or 6-months systemic treatment The patients should be stopped all systemic or topical medications at least one month before enrollment to the study
Exclusion criteria
Exclusion criteria: Pregnancy lactation Hb50% or >25% by lower doses of drug(25-50% over 2weeks)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lichen planopilaris activity. Timepoint: Before and after 2,4,6 months after intervention. Method of measurement: Checklist of criteria in lichen planopilaris activity index ; Lichen planopilaris activity index is measured by this formula:LPPAI = (itch + pain + burn ) / 3 + (scalp erythema + perifollicular erythema +perifollicular scale) / 3 + 2.5(pull test) + 1.5(spreading / 2).;Standardized global photography. Timepoint: Before and after intervention. Method of measurement: Based on scoring by two dermatologists. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMinoo Jelvan,MD
Esfahan University of Medical Sciences
Outcome results
None listed