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Comparison of the effect of vasopressin and tranexamic acid on gastrointestinal bleeding

Comparison of the effect of tranexamic acid and vasopressin on the outcome of severe gastrointestinal bleeding in patients referred to the emergency department

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190717044255N2
Enrollment
120
Registered
2020-11-13
Start date
2020-11-21
Completion date
Unknown
Last updated
2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal bleeding. Gastrointestinal hemorrhage, unspecified

Interventions

Intervention 1: Control group: 30 patients will be treated with standard gastrointestinal bleeding treatment and the first placebo of normal saline will be infused 100 cc in 20 minutes and then 100 cc

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All patients with a diagnosis of severe upper or lower gastrointestinal bleeding

Exclusion criteria

Exclusion criteria: Previous allergy to vasopressin or tranexamic acid coagulation disorders Suspected acute myocardial infarction

Design outcomes

Primary

MeasureTime frame
Gastrointestinal bleeding volume. Timepoint: During the first 24 hours after receiving the drug. Method of measurement: Using a Calibrated container or non-sterile gas (each blood gas completely impregnate with equivalent to 20 ml blood ).

Secondary

MeasureTime frame
Blood pressure. Timepoint: Every 30 minutes to 24 hours after receiving the drug. Method of measurement: Automatic arm pressure gauge cuff.;Pulse rate. Timepoint: Every 30 minutes to 24 hours after receiving the drug. Method of measurement: Pulse oximeter device.;Patients venous hemoglobin concentration. Timepoint: When patients are admitted to the emergency room and then every 6 hours, up to 24 hours after receiving the drug. Method of measurement: Based on laboratory results by Cell counter device model H1.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSimin najafgholian

Arak University of Medical Sciences

info@arakmu.ac.ir00980863136055

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026