The effect of aminophylline and paracetamol administration on headache

The Efficacy of Prophylactic Intravenous Aminophylline, Paracetamol or Aminophylline and Paracetamol in Prevention of Post spinal headache in lower extremity surgeries Compared to the Control Group

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190717044246N1

Enrollment

120

Registered

2019-08-25

Start date

2016-03-20

Completion date

Unknown

Last updated

2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal Anesthesia. Other complications of spinal and epidural anesthesia during labor and delivery

Interventions

Intervention 1: intervention group 1: 1.5 mg / kg aminophylline, intra venously, The drugs were injected 15 minutes before the end of surgery. Intervention 2: intervention group 2: 1000 mg paracetamol

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age range of 20-50 years, candidate for lower extremity surgery Normal blood pressure

Exclusion criteria

Exclusion criteria: Migraine history Get analgesic 24 hours before surgery Underlying disease

Design outcomes

Primary

Measure	Time frame
Headache severity. Timepoint: Before the spinal anesthesia, 15 minutes before recovery, the first day every 6 hoursl and the first week daily. Method of measurement: Visual Analogue Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomayeh Asadpoor

Esfahan University of Medical Sciences

rahgozar.m.b@gmail.com+98 31 3554 2381

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026