COVID-19. COVID-19
Conditions
Interventions
Intervention 1: Intervention group: Patients with coronavirus 19 who undergo mesenchymal stem cell transplantation at a rate of 2 million per kilogram body weight (based on IBW) through peripheral blo
Sponsors
Barakat Pharmaceutical Group
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
17 Years to 65 Years
Inclusion criteria
Inclusion criteria: Persistent hypoxemia despite receiving less than 93% Saturation oxygen Respiratory failure requires a Ventilator Chest has multilobar infiltrates
Exclusion criteria
Exclusion criteria: Patient dissatisfaction Pregnant patient Age under 18 years and over 65 years Patient with known active malignancy Shock Organ failure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response. Timepoint: 28 days-From the time of cell injection until the 28th day. Method of measurement: clinical observation by Infectious Diseases Specialist.;O2 saturation. Timepoint: Since the injection of the cell; 0,3,6 days. Method of measurement: ventilator. | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammation cytokines. Il-6 & Il-10. Timepoint: On days 0,3,6,14 - from the time of cell injection. Method of measurement: Assay by the Elisa.;CD4 and CD8 markers. Timepoint: On days 0,3,6,14 - from the time of cell injection. Method of measurement: Flow Cytometry.;Evaluation of lung function. Timepoint: On days 0,14 - from the time of cell injection. Method of measurement: CT scan of the lungs. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahshid Saleh - Dr Iman seyhoun
Tehran University of Medical Sciences
Outcome results
None listed