Impact of metformin on pregnancy outcomes in overweight women

Evaluating the effect of Metformin administration on pregnancy outcomes in healthy overweight pregnant women

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190716044229N1

Enrollment

350

Registered

2020-02-06

Start date

2019-07-16

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy outcomes in overweight pregnancies.

Interventions

Intervention 1: Intevention group:oral metformin500 mgr/twice a day,( manufactured in Iran) from 12-16week until delivery. Intervention 2: Control group:placebo with chemical composition:(Starch200mg/

Eligibility

Sex/Gender

Female

Age

16 Years to No maximum

Inclusion criteria

Inclusion criteria: Maternal age >=16 years Singelton pregnancy Body mass index: 25<=BMI<30 Negative history of Diabetes Mellitus Negative history of previous medical conditions Gestational age between 12 & 16 weeks

Exclusion criteria

Exclusion criteria: Multiple gestation Positive history of general medical conditions (e.g. diabetes) BMI=30

Design outcomes

Primary

Measure	Time frame
Frequency of fetal macrosomia. Timepoint: Post-partum. Method of measurement: Neonatal weighing scale.;Incidence of gestational diabetes mellitus. Timepoint: From gestational age 24 weeks onward. Method of measurement: Three hour glucose tolerance test.;Incidence of preeclampsia. Timepoint: Fromgestational age 20 weeks onward. Method of measurement: Measurement of blood pressure and relevant laboratory analyses.;Gestational weight gain monitoring. Timepoint: From baseline until delivery. Method of measurement: Weighing scale.	—

Measure

Time frame

Frequency of fetal macrosomia. Timepoint: Post-partum. Method of measurement: Neonatal weighing scale.;Incidence of gestational diabetes mellitus. Timepoint: From gestational age 24 weeks onward. Method of measurement: Three hour glucose tolerance test.;Incidence of preeclampsia. Timepoint: Fromgestational age 20 weeks onward. Method of measurement: Measurement of blood pressure and relevant laboratory analyses.;Gestational weight gain monitoring. Timepoint: From baseline until delivery. Method of measurement: Weighing scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamira Esmaili

Oroumia University of Medical Sciences

samiraesmaili2019@yahoo.com+98 44 3232 7077

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026