Evaluating the Therapeutic Effect of Theophylline and Zinc Sulfate Co-administration in Infertile Men

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190714044209N1

Enrollment

120

Registered

2020-02-06

Start date

2019-12-22

Completion date

Unknown

Last updated

2020-02-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertile men. Male infertility

Interventions

Intervention 1: Intervention group: Theophylline (200 mg/day for 3 months period). Intervention 2: Intervention group: Zink sulfate (220 mg/day for 3 months period). Intervention 3: Intervention group

Eligibility

Sex/Gender

Male

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Infertile men who, despite having at least one year of unprotected intercourse, have not had fertility in their spouse. These men will all be married According to WHO criteria, abnormalities in sperm parameters should be observed in at least two sperm samples within 2 weeks. These men will be between the ages of 20 and 50.

Exclusion criteria

Exclusion criteria: Single men Men with varicoceles or any other specific disease Men who have taken a particular drug for the past three months

Design outcomes

Primary

Measure	Time frame
Semen analysis. Timepoint: Before intervention. Method of measurement: CASA (Computer-aided sperm analysis) system.;Hormones analysis. Timepoint: Before intervention. Method of measurement: ELISA Kit.;Malondialdehyde (MDA) level. Timepoint: Before intervention. Method of measurement: ELISA Kit.;Total antioxidant capacity (TAC). Timepoint: Before intervention. Method of measurement: ELISA Kit.;DNA fragmentation. Timepoint: Before intervention. Method of measurement: SDFA (Sperm DNA Fragmentation Analysis) kit.;Levels of inflammatory factors. Timepoint: Before intervention. Method of measurement: ELISA Kit.;Sperm viability. Timepoint: Before intervention. Method of measurement: Eosin-Negrosin Staining.;Sperm maturation. Timepoint: Before intervention. Method of measurement: Aniline blue staining kit.;Investigation of changes in gene expression level. Timepoint: Before intervention. Method of measurement: Real-time polymerase chain reaction (RT-PCR).;Protein levels measurement. Timepoint: Before intervention. Method of measurement: Western blot.	—

Measure

Time frame

Semen analysis. Timepoint: Before intervention. Method of measurement: CASA (Computer-aided sperm analysis) system.;Hormones analysis. Timepoint: Before intervention. Method of measurement: ELISA Kit.;Malondialdehyde (MDA) level. Timepoint: Before intervention. Method of measurement: ELISA Kit.;Total antioxidant capacity (TAC). Timepoint: Before intervention. Method of measurement: ELISA Kit.;DNA fragmentation. Timepoint: Before intervention. Method of measurement: SDFA (Sperm DNA Fragmentation Analysis) kit.;Levels of inflammatory factors. Timepoint: Before intervention. Method of measurement: ELISA Kit.;Sperm viability. Timepoint: Before intervention. Method of measurement: Eosin-Negrosin Staining.;Sperm maturation. Timepoint: Before intervention. Method of measurement: Aniline blue staining kit.;Investigation of changes in gene expression level. Timepoint: Before intervention. Method of measurement: Real-time polymerase chain reaction (RT-PCR).;Protein levels measurement. Timepoint: Before intervention. Method of measurement: Western blot.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAtena Sadat Azimi

Arak University

a-azimi@phd.araku.ac.ir+98 86 3277 7300

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026