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Safety and efficacy of Amniotic Membrane in Asherman's syndrome management

Safety and efficacy of Amniotic Membrane in Asherman's syndrome management

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190714044201N1
Enrollment
10
Registered
2019-09-15
Start date
2019-07-11
Completion date
Unknown
Last updated
2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asherman's Syndrome. Intrauterine synechiae

Interventions

Patients with Asherman syndrome After Hysteroscopy and adhesions release, the amniotic membrane is placed on the uterine balloon stent and inserted into the uterus. Then 5cc normal saline is injected

Sponsors

Sarem Fertility and Infertility Research Center
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Asherman's patients with intrauterine adhesions and endometrial atrophy endometrial thickness of less than 5 mm normal functioning of the heart kidneys and lungs wish to complete the study

Exclusion criteria

Exclusion criteria: Unwilling to get pregnant Genital tract inflammation Cardiovascular diseases Hormonal Problems Contraceptive Indication of Relative Hormone Therapy Gastrointestinal diseases prohibits estrogen use liver or chronic hepatic failure Immune system diseases such as lupus, ... Past and present cancer Positive serologic evidence of previous or current hepatitis B and C infection as well as HIV and HTLV

Design outcomes

Primary

MeasureTime frame
Menstruation. Timepoint: At baseline and 3 and 6 months after intervention. Method of measurement: Number of menstruation days, pads number.;Endometrial thickness. Timepoint: At baseline and 3 and 6 months after intervention. Method of measurement: Ultrasound.

Secondary

MeasureTime frame
Pregnancy Rate. Timepoint: 12 month 3 month time frame. Method of measurement: Pregnancy routine tests.;Implantation Rate. Timepoint: Pregnancy routine tests. Method of measurement: Ultrasound.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. aboTaleb saremi

Sarem Infertility Fertility Research Center

dr.mahmoodinia@sarem.org+98 21 4467 0883

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026