The effect of N-Acetyl cystein on decreasing the flare in ulcerative colitis

Study of the effect of N-Acetyl cystein on flare rate in ulcerative colitis with gradual dose reduction of glucocorticoids

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190713044185N1

Enrollment

160

Registered

2019-08-26

Start date

2019-07-23

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis. Ulcerative colitis

Interventions

Intervention 1: Intervention group: N-acetyl cystein 400 mg twice a day for 16weeks from hexal company. Intervention 2: Control group: Placebo containing corn starch twice a day for 16 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Ulcerative colitis patients treated with high dose glucocorticoids (1 mg/kg to 5 mg) Aged between 18-75 years

Exclusion criteria

Exclusion criteria: Pregnancy Having other systemic disease such as heart failure, kidney failure and lung failure Using Anti TNF drugs

Design outcomes

Primary

Measure	Time frame
Relapse based on Mayo score and clinical symptoms. Timepoint: every 2 weeks for 16 weeks. Method of measurement: mayo score questionnaire and using clinical symproms.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSimin Sotoodeh

Tabriz University of Medical Sciences

drsiminsotoodeh@gmail.com+98 41 3335 1688

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026