chronic anal fissure. Chronic anal fissure
Conditions
Interventions
Intervention 1: Intervention group: L-arginine supplement, manufactured by Karen Company, 90 capsules consumed 3 times daily (3 grams of arginine per day) with their meals for one month. Intervention
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Chronic Anal Fischer Fisher in the posterior and anterior areas of the anus Non-pregnant and lactating women Age: 18 - 65 years BMI: 18.5 - 35 kg/m2 Non-specific digestive diseases such as Crohn's disease, Ulcerative colitis, gastrointestinal cancers and etc. The absence of diseases that fissure can be their complications: tuberculosis, AIDS, syphilis, herpes, leukemia and etc. No history of malignancy or malignancy in present No history of heart disease No history of fissure and hemorrhoid surgery
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical symptoms (bleeding). Timepoint: at the beginning and the end of the study. Method of measurement: Visual Analogue Scale.;Clinical symptoms (pain). Timepoint: at the beginning and the end of the study. Method of measurement: Visual Analogue Scale.;Clinical symptoms (improve ulcer ). Timepoint: at the beginning and the end of the study. Method of measurement: Visual Analogue Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: at the beginning and end of the study. Method of measurement: General Health Survey Short Form-36.;Internal anal sphincter pressure. Timepoint: at the beginning and end of the study. Method of measurement: manometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMasoumeh Khalighi Sikaroudi
Iran University of Medical Sciences
Outcome results
None listed