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Effect of ANSIL on the aphthous

Effect of ANSIL(Silver nanoparticles) to improve recurrent aphthous stomatitis: a double-blind clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190701044062N6
Enrollment
80
Registered
2021-06-26
Start date
2021-07-06
Completion date
Unknown
Last updated
2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

recurrent aphthous stomatitis. Recurrent oral aphthae

Interventions

Intervention 1: Intervention group:20 patients with oral aphthous receive a solution of ANCIL at a dose of 0.5 twice a day. Intervention 2: Intervention group: 20 patients with oral aphthous receive a

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Minor and solitary aphthous ulcers in the lip mucosa or cheek Age range 18 to 40 years

Exclusion criteria

Exclusion criteria: Pregnant Breastfeeding Patients with systemic disease Patients with herpetiform ulcers and multiple major or minor aphthous ulcers for more than 4 days Patients who refuse to participate in the study

Design outcomes

Primary

MeasureTime frame
Comparison of different doses of ANCIL and placebo solution on the recovery time of recurrent oral aphthous. Timepoint: 80 patients will be divided into 4 groups of 20 and 3 groups of patients will receive doses of 0.5, 1, and 2 ANCIL solution. The fourth group will receive the basic formulation of the solution without active components. The duration of use of the solutions will be a maximum of 7 days. Then the duration of complete recovery of the oral aphthous in the groups will be compared. Method of measurement: Different doses are compared based on the patient's clinical symptoms and observing the speed of oral aphthous recovery.;Pain intensity in patients with recurrent oral aphthous. Timepoint: On days 0, 5 and 7. Method of measurement: VAS questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Yousefipour

Tabriz University of Medical Sciences

ali_you_2015@yahoo.co.uk+98 41 3662 8155

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026