Evaluation of Effects of ABCDE Bundle on Hemodynamics and risk of complication in Patients with Mechanical Ventilation

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190625044000N1

Enrollment

Registered

2019-10-13

Start date

2019-07-21

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients on Mechanical Ventilation. Dependence on respirator

Interventions

Intervention 1: Intervention group: In patients with mechanical ventilation, ABCDE bundle is administered for 7 days. The ABC protocol runs according to the protocol, the wake and breathing coordinati

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Have written consent to participate in the research Age over 18 years The duration of stay in the ICU is more than 48 hours Duration of use of sedative and analgesics 48 hours and more... The duration of mechanical ventilation is 48 hours and more Endotracheal tube patient RASS score> _ -3 Apache score <20 The subgroup of pulmonary patients (COPD, ARDS, pneumonia, embolism, etc.)

Exclusion criteria

Exclusion criteria: History of epilepsy Disorders of the limb Neuromascular disease (myasthenia grave, muscular spastic atrophy, etc.) and a disease with neuromuscular complications (lead poisoning, etc.)

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: Monitoring Vital Signs(BED SIDE).;Mean arterial pressure. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: blood pressure gauge.;Pulse pressure. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: blood pressure gauge.;PaO2 / FiO2. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: Arterial Blood Gas Test(ABG).;Delirium. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: The Confusion Assessment Method (CAM)-ICU.;Risk of deep vein thrombosis. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: Wells score.;Risk of Incidence pressure ulcers. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: Conscious level-Mobility-Haemodynamics-Oxygenation-Nutrition Index (COMHON).	—

Measure

Time frame

Heart rate. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: Monitoring Vital Signs(BED SIDE).;Mean arterial pressure. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: blood pressure gauge.;Pulse pressure. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: blood pressure gauge.;PaO2 / FiO2. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: Arterial Blood Gas Test(ABG).;Delirium. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: The Confusion Assessment Method (CAM)-ICU.;Risk of deep vein thrombosis. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: Wells score.;Risk of Incidence pressure ulcers. Timepoint: The days of T0, T1, T3, T5, T7. Method of measurement: Conscious level-Mobility-Haemodynamics-Oxygenation-Nutrition Index (COMHON).

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Secondary

Measure	Time frame
Length of admission to ICU. Timepoint: Initially, at the time of discharge, the ICU (in both groups). Method of measurement: The number of days the patient is admitted to the ICU.;The length of hospitalization. Timepoint: At the beginning of the study and at the time of hospital discharge (in both groups). Method of measurement: The number of days the patient was hospitalized.;Mechanical ventilation time. Timepoint: At the beginning of the study and at the time of weaning from mechanical ventilation (in both groups). Method of measurement: The number of days the patient was under mechanical ventilation.	—

Measure

Time frame

Length of admission to ICU. Timepoint: Initially, at the time of discharge, the ICU (in both groups). Method of measurement: The number of days the patient is admitted to the ICU.;The length of hospitalization. Timepoint: At the beginning of the study and at the time of hospital discharge (in both groups). Method of measurement: The number of days the patient was hospitalized.;Mechanical ventilation time. Timepoint: At the beginning of the study and at the time of weaning from mechanical ventilation (in both groups). Method of measurement: The number of days the patient was under mechanical ventilation.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Ghouchani

Mashhad University of Medical Sciences

Ghouchanim9@mums.ac.ir+98 51 4622 4165

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026