Studying the effect of sterile" municipal water "on the systemic inflammatory response syndrome

Studying the effect of sterile municipal water as a flushing fluid on systemic response syndrome after percutaneous nephrolithotomy surgery: a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190624043991N37

Enrollment

200

Registered

2026-04-20

Start date

2027-04-21

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kidney stone. Renal calculus or stone

Interventions

Intervention 1: Intervention group: In this group, instead of using physiological saline, which is routinely used during percutaneous nephrolithotomy surgery to wash the patient's ducts, municipal wat

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: People over the age of 18. Patients are candidates for Percutaneous Nephrolithotomy surgery (PCNL).

Exclusion criteria

Exclusion criteria: Have a history of receiving chemotherapy. Have a fever and active infection. Have a history of long-term corticosteroid consumption. Have systemic inflammatory diseases. Have a positive urine culture.

Design outcomes

Primary

Measure	Time frame
Systemic inflammatory response syndrome (SIRS). Timepoint: In this study, to measure the effect of sterilized municipal water in surgery on systemic inflammatory response syndrome, patients will be examined by the attending physician once in the recovery room after the intervention and once 24 hours after the intervention, and their symptoms of systemic inflammatory response syndrome will be recorded. Method of measurement: Systemic inflammatory response syndrome is assessed by examination and recording (body temperature, respiratory rate, and heart rate) by the attending physician and by blood test (leukocyte count) in the laboratory. If two of these criteria are abnormal, systemic inflammatory response syndrome is considered positive.	—

Measure

Time frame

Systemic inflammatory response syndrome (SIRS). Timepoint: In this study, to measure the effect of sterilized municipal water in surgery on systemic inflammatory response syndrome, patients will be examined by the attending physician once in the recovery room after the intervention and once 24 hours after the intervention, and their symptoms of systemic inflammatory response syndrome will be recorded. Method of measurement: Systemic inflammatory response syndrome is assessed by examination and recording (body temperature, respiratory rate, and heart rate) by the attending physician and by blood test (leukocyte count) in the laboratory. If two of these criteria are abnormal, systemic inflammatory response syndrome is considered positive.

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Secondary

Measure	Time frame
Hemoglobin. Timepoint: To investigate the effect of sterile municipal water used in surgery on the patient's hemoglobin level, the patient's hemoglobin is measured and compared the day before and after surgery. Method of measurement: Medical diagnosis laboratory With hemoglobinometry tool.;Hematocrit. Timepoint: To investigate the effect of sterile municipal water used in surgery on the patient's hematocrit level, the patient's hematocrit is measured and compared the day before and after surgery. Method of measurement: Medical diagnostic laboratory with microhematocrit centrifuge.;Complications after surgery. Timepoint: One week after surgery, complications observed in patients in the intervention group are reviewed and recorded and compared with complications in the control group. Method of measurement: Based on the clavein dindo table.	—

Measure

Time frame

Hemoglobin. Timepoint: To investigate the effect of sterile municipal water used in surgery on the patient's hemoglobin level, the patient's hemoglobin is measured and compared the day before and after surgery. Method of measurement: Medical diagnosis laboratory With hemoglobinometry tool.;Hematocrit. Timepoint: To investigate the effect of sterile municipal water used in surgery on the patient's hematocrit level, the patient's hematocrit is measured and compared the day before and after surgery. Method of measurement: Medical diagnostic laboratory with microhematocrit centrifuge.;Complications after surgery. Timepoint: One week after surgery, complications observed in patients in the intervention group are reviewed and recorded and compared with complications in the control group. Method of measurement: Based on the clavein dindo table.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Zahra Navi

Tehran University of Medical Sciences

shahrzadn951@gmail.com+98 21 6634 8593

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026