Effects of dexamethasone and mannitol combination in PCNL surgery on the incidence of SIRS

Study of the effect of the combination of dexamethasone and mannitol during PCNL surgery on the incidence of postoperative SIRS

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190624043991N32

Enrollment

125

Registered

2025-08-10

Start date

2026-01-20

Completion date

Unknown

Last updated

2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kidney stones. Calculus of the lower urinary tract

Interventions

Intervention 1: Intervention group: Dexamethasone group: At the beginning of anesthesia after tracheal intubation, 8 mg of dexamethasone is added to the normal saline serum received. Intervention 2: I

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Be over 18 years of age. The first step should be stone surgery. Have signed the consent form.

Exclusion criteria

Exclusion criteria: Have a history of diabetes. Have a history of receiving corticosteroids and chemotherapy. Have fever, active infection, and CRP above 505 Have blood transfusions and embolization after surgery. Have bilateral kidney stones. Have kidney and ureter stones at the same time. Have urinary system anomalies. Have Chronic Kidney Disease Have a previous double J installation

Design outcomes

Primary

Measure	Time frame
Incidence of systemic inflammatory response syndrome after percutaneous Percutaneous Nephrolithotripsy. Timepoint: End of surgery after removal of the endotracheal tube and 24 hours after surgery. Method of measurement: Medical laboratory.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Zahra Navi

Tehran University of Medical Sciences

shahrzadn951@gmail.com+98 21 6634 8560

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026