kidney stone disease. Acute nephritic syndrome
Conditions
Interventions
Intervention 1: "Intervention group": 50 patients receiving antibiotics along with antiandrogen medication (finasteride). Intervention 2: "Control group": 50 patients receiving antibiotics.
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Individuals who are 18 - 70 years old. Patients who are candidates for PCNL surgery. Kidney stones typically range in size from 2 to 4 centimeters. They have no history of immune system deficiency.
Exclusion criteria
Exclusion criteria: Have a history of recent chemotherapy. Have a fever and active infection. Have a history of long-term corticosteroid use. Have stones larger than 4 cm. Have systemic inflammatory diseases. Their urine culture is positive. Have a long surgery or require more than one unit of blood transfusion during the procedure. Have a history of neuropsychiatric illnesses such as depression and schizophrenia. Have a severe drug allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systemic inflammatory response syndrome (SIRS). Timepoint: To assess the patients' systemic function, the attending physician will examine and record vital signs once in the postoperative recovery room and once 24 hours after surgery. Method of measurement: .Blood and urine samples from patients are collected 24 hours before and after surgery. Urine analysis, hemoglobin, hematocrit, body temperature, systemic carbon dioxide, circulating cells, and C-reactive protein were recorded and analyzed by the medical diagnostic laboratory for comparison before and after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes and incidence sepsis, and other complications of PCNL due to use and non-use of finasteride. Timepoint: 48 Hours. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Zahra Navi
Tehran University of Medical Sciences
Outcome results
None listed