Skip to content

Study of the effect of statins on migraine

Evaluation of the effectiveness of Atorvastatin and Nortriptyline in prophylaxis of migraine attacks in patients whit classic migraine compared to standard treatment Nortriptyline: a randomized triple blind controlled clinical trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190620043953N2
Enrollment
60
Registered
2020-04-02
Start date
2019-07-06
Completion date
Unknown
Last updated
2020-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

migraine headaches. Migraine

Interventions

Intervention 1: Management group: In this group Atorvastatin 40mg tablets from Abidi company, once a day and Nortriptyline 25mg tablets from Abidi company, once a day for 24 days will be used and afte
from Yazd University of Medical Sciences laboratory, once daily and Nortriptyline 25mg tablets from Abidi company once a day, for 24 days will be used your and after 4, 14 and 24 week use a visit and

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age 18 to 65 years old Having at least 3 migraine attacks per month Patients who have fewer than three attacks per month Provided that the severity of the attacks is high and affects the person's life. Having a normal serum level of vitamin D3 Sufficient literacy to understand the study, use of medication and possible side effects

Exclusion criteria

Exclusion criteria: Patients who do not sign a moral consent form. Patients with chronic headaches (more than 15 attacks per month). Patients receiving statin due to other diseases, such as diabetes, dyslipidemia, coronary artery disease, peripheral vascular disease, etc. Patients with severe renal insufficiency (GFR <30 ml / min) Failure to co-operate to continue treatment

Design outcomes

Primary

MeasureTime frame
Frequency of migraine headache attacks. Timepoint: 24 weeks after the start of the study. Method of measurement: Number of attacks in a month based on patient statements.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoya Rahmany

Yazd University of Medical Sciences

royarahmany9@gmail.com+98 35 3830 0940

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026