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The effect of diphenhydramine on adenotonsillectomy

Comparison of diphenhydramine and placebo on the side effect of tonsillectomy

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190618043934N5
Enrollment
66
Registered
2020-07-04
Start date
2020-06-19
Completion date
Unknown
Last updated
2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tonsillitis. Acute tonsillitis

Interventions

Intervention 1: Intervention group: Patients taking diphenhydramine as a anesthetic in the tonsil bed receive 1.25 mg / kg up to a maximum of 8 mg 5 minutes before surgery. Intervention 2: Control gro

Sponsors

Birjand University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
5 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age between 5 and 50 years Patients with ASA classes 1 and 2 No history of liver disease Lack of bronchial asthma Lack of bladder disease No pregnancy and lactation Lack of blood pressure during pregnancy or preeclampsia No history of kidney disease

Exclusion criteria

Exclusion criteria: Coagulation disorder Simultaneous surgery of the patient with other oral and pharyngeal problems Allergic reactions known to antihistamines Allergic reactions known to benzodiazepines or topical anesthetics Having an acute pharyngeal infection

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: 0, 6, 12 and 24 hours after surgery. Method of measurement: Using the VAS Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZabihullah Mohaghegh

Birjand University of Medical Sciences

oabstudent@gmail.com+98 56 3232 3232

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026