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Comparison of the effectiveness of sertraline and Nortriptyline on anxiety and gastrointestinal symptoms in patients with irritable bowel syndrome

Comparison of the effectiveness of sertraline and Nortriptyline on anxiety and gastrointestinal symptoms in patients with irritable bowel syndrome: A double-blind clinical trial study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190618043934N13
Enrollment
192
Registered
2021-08-12
Start date
2021-08-06
Completion date
Unknown
Last updated
2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

irritable bowel syndrome. Irritable bowel syndrome

Interventions

Intervention 1: Intervention group: The first group in the interventional study are patients who are given sertraline 50 mg daily (Abidi Pharmaceutical Company made in Iran) for one month. Interventi

Sponsors

Birjand University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age 18 to 50 years Patient consent to participate in the study

Exclusion criteria

Exclusion criteria: Lack of patient cooperation to participate in further study History of gastrointestinal cancer History of neurological disorder Pregnancy and lactation Bipolar or bipolar patients Contraindications to the use of two drugs sertraline and nortriptyline Use of antidepressants and anti-anxiety drugs Allergy to prescription drugs Co-occurring with serious physical illnesses such as heart disease, multiple sclerosis Having a psychotic illness such as schizophrenia and related disorders Substance abuse and substance abuse

Design outcomes

Primary

MeasureTime frame
Anxiety. Timepoint: At the beginning of the study and one month after the start of the intervention in patients. Method of measurement: Beck Anxiety Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZabihullah Mohaghegh

Birjand University of Medical Sciences

zabihullahmohaghegh@gmail.com+98 56 3238 3232

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026