Ventilator-associated pneumonia. Pneumonia due to Klebsiella pneumoniae
Conditions
Interventions
Intervention 1: Colistin 9MIU loading dose as iv infusion over 1 hour then 4.5MIU every 12 hour as iv infusion over 1 hour + Colistin nebulized 2 MIU every 8 hour using jet nebulizer for at least 7 da
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Inclusion criteria
Inclusion criteria: Diagnosis of pneumonia 48 hours after intubation (radiographical, laboratory and clinical findings along with a positive tracheal aspirate culture)
Exclusion criteria
Exclusion criteria: Signs of previous pneumonia at the time of intubation No concomitant antibiotics indicated to treat pneumonia other than the study (but allowed for other infections) Patients with a positive culture but no clinical and radiological findings for pneumonia An antibiogram sensitive to any antibiotocs else than polymixins Any history of allergy and seizure caused by Carbapenems/Colistin
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response of pneumonia to the treatment regimen. Timepoint: Days 2 and 7. Method of measurement: Evaluating vital signs, oxygenation, laboratory and hemodynamic parameters.;Incidence of acute kidney injury. Timepoint: Days 2 and 7. Method of measurement: According changes in serum creatinine levels and urine volume. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Khalili
Tehran University of Medical Sciences
Outcome results
None listed