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Comparison of preemptive analgesic effect of Naproxen, Celecoxib and Acetaminophen codeine on pain control after mandibular third molar surgery

Comparison of preemptive analgesic effect of Naproxen, Celecoxib and Acetaminophen codeine on pain control after mandibular third molar surgery in patients to dentistry clinic of bushehr university of medical sciences

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20190615043899N1
Enrollment
78
Registered
2019-07-16
Start date
2019-02-20
Completion date
Unknown
Last updated
2019-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Control of pain after third molar surgery. Injury, poisoning and certain other consequences of external causes

Interventions

Intervention 1: Control group: In this study, acetaminophen codein was used as a standard dose (control) to evaluate the efficacy of other drugs
So, half an hour before, surgery was given to a group of acetaminophen 325 mg. Intervention 2: Intervention group: Half an hour before surgery, naproxen 250 mg (Pars Dara Company) was givenby this gr

Sponsors

Boushehr University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patient OPG to confirm that the hardness of the lower third molar is the same. Patient-patient pain rating History of systemic diseases Patient should not have a history of hypersensitivity to steroid drugs Patient in the range of 18 to 60 years old Avoid taking an hour before taking analgesic A person can read and understand the checklist The patient does not take analgesic because of chronic pain

Exclusion criteria

Exclusion criteria: There is an infection of the postoperative dry socket Diabetic patients Systemic drug interactions with the three drugs in this study Use of psychological drugs The presence of rotting teeth or needing treatment in the mouth Lack of cooperation for future referrals Systemic disease People who had started treating the wound of the gastrointestinal tract for 30 days before surgery Used analgesics or another drug for 24 hours before surgery History of narcotic or analgesic addiction Patients who were pregnant or Breastfeeding Known sensitivity to anti-inflammatory drugs, non-steroidal anti-inflammatory drugs ordinary or cyclooxygenase-2 inhibitors

Design outcomes

Primary

MeasureTime frame
The severity of pain. Timepoint: The severity of pain was the patient who was recorded in the questionnaire during the prescribed hours (7 days and 72, 48, 24, 12, 8, 4). Method of measurement: The severity of pain was as follows: the patient, based on her sense of pain, determined a number between 10-1 according to the definition of the pain states based on the degree of discomfort / pain. The number 1 indicates that the patient feels good and does not feel pain, and the number 10 indicates a painful pain, to the extent that the patient leaves all his work and feels the need for rest.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Mehdi Hosseini

Boushehr University of Medical Sciences

pmn.hsn30067@gmail.com+98 77 3344 8061

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026