Major Depressive Disorder Resistant to First-line Pharmaceutical Therapy. F33
Conditions
Interventions
Intervention 1: • The rTMS protocol is performed by a MagVenture device (Denmark) with an 8-shaped coil equipped with a cooling system. Before each rTMS session, participants' motor threshold (MT) is
Sponsors
Qazvin University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria were the age of 18 to 70 years Primary diagnosis of MDD by a psychiatrist based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders version V (DSM-V). the patients whose MDD was approved by a specialist according to MDD criteria and who had received and failed to respond to an episode of treatment (for at least six weeks) with effective tolerated doses of antidepressants were included in the study. The patients should have received the same medication from six weeks to the onset of the study and continued taking the drug during the study. Exclusion criteria comprised the presence of underlying diseases History of rTMS treatment due to any disorder History of seizures or neurosurgery, Having a pacemaker Pregnancy Being diagnosed with a high risk of suicide, substance abuse, and unwillingness to participate in the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression symptoms. Timepoint: At baseline (before intervention) and the second and fourth weeks after intervention. Method of measurement: The Hamilton Rating Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of the disease. Timepoint: At baseline (before intervention) and the second and fourth weeks after intervention. Method of measurement: Clinical Global Impression–Severity scale (CGI-S).;Illness Perception. Timepoint: At baseline (before intervention) and the second and fourth weeks after intervention. Method of measurement: the Brief Illness Perception Questionnaire (Brief IPQ). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Haji Seyed Javadi
Qazvin University of Medical Sciences
Outcome results
None listed