Effect of nano-silver mouthwash on white spot lesion, gingival status and inflammatory biomarkers in patients undergoing fixed braces. (randomized double blind clinical trial)

Effect of nano-silver mouthwash on white spot lesion, gingival status and inflammatory biomarkers in patients undergoing fixed orthodontic treatment. (randomized double blind clinical trial)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190611043870N1

Enrollment

Registered

2019-12-21

Start date

2020-01-01

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enamel demineralization and gingivitis in orthodontic patients. patients with fixed orthodontic appliance

Interventions

Intervention 1: Control group: Patients use CHX Mouthwash 0/012% for 30 seconds twice daily for 6 months during Orthodontic treatment. Intervention 2: Intervention group 1: patients use fluoride Mout

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Full fixed appliance treatment involving upper and lower dentitions for a minimum of six months duration. Mild (up to 3mm spacing) to moderate (4-6mm space required) class l malocclusion. Age group rang from 18-40 years of age. Good oral hygiene Non-extraction treatment plan Healthy, non-smoker with no systemic medical conditions and no routine medications

Exclusion criteria

Exclusion criteria: Antibiotic use during preceding month. Patients who received antibiotics prophylaxis or any systematic medication within 3 months prior to the study. Patients who take medications that affect salivary flow (e.g. antidepressant, diuretics, antihistamines, narcotics and B adrenorecepter agonist). Smokers. Evidence of periodontitis. Dentofacial deformities (cleft palate, hemifacial,microsomia, etc….) Pregnant and lactating women. patient with clinical signs of gingivitis. patient with systematic disorder that could alter the periodontal conditions prior to bracket bonding. Presence of impacted teeth. Presence of pretreatment white spot lesions.

Design outcomes

Primary

Measure	Time frame
White spot lesion. Timepoint: before intervention, 30 days, 90 days and 180 days after intervention. Method of measurement: photography.;Gingival status. Timepoint: before intervention,24 hours, 30 days, 90 days and 180 days after intervention. Method of measurement: clinical examination.;Inflammatory biomarkers. Timepoint: before intervention, 24 hours, 30 days, 90 days and 180 days after intervention. Method of measurement: ELISA test.	—

Measure

Time frame

White spot lesion. Timepoint: before intervention, 30 days, 90 days and 180 days after intervention. Method of measurement: photography.;Gingival status. Timepoint: before intervention,24 hours, 30 days, 90 days and 180 days after intervention. Method of measurement: clinical examination.;Inflammatory biomarkers. Timepoint: before intervention, 24 hours, 30 days, 90 days and 180 days after intervention. Method of measurement: ELISA test.

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Countries

Iraq

Contacts

Public ContactHadi M. Ismail

The University of Sulaimani

hadi.ismail@univsul.edu.iq+964 53 327 0913

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026