Effect of reduced dose of long-acting GnRH agonist versus short acting GnRH agonist

Evaluation of the effect of reduced dose of long-acting gonadotropin releasing hormone (GnRH) agonist versus short acting GnRH agonist on pregnancy outcome in patients undergoing intracytoplasmic sperm injection outcome- clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190609043845N1

Enrollment

400

Registered

2019-06-20

Start date

2019-07-29

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group: long-acting gonadotropin releasing hormone (GnRH) agonist: Decapeptyl (1.25mg, Ferring) will be injected on 21st day of menstruation before the start of ovarian ind

Eligibility

Sex/Gender

Female

Age

No minimum to 40 Years

Inclusion criteria

Inclusion criteria: Age = 40 years Basal FSH level <8 Less than one failed ICSI cycle Non PCOS patients No azoospermia No moderate to severe endometriosis

Exclusion criteria

Exclusion criteria: No response to ovulation induction Difficult embryo transfer Bloody embryo transfer

Design outcomes

Primary

Measure	Time frame
Biochemical pregnancy rate. Timepoint: Two month after intervention. Method of measurement: Positive ßhCG test (Lab kit).;Clinical pregnancy rate. Timepoint: Two month after intervention. Method of measurement: Assessment of gestational sac and fetal heartbeat at 7 weeks of gestation (Vaginal ultrasonography).	—

Secondary

Measure	Time frame
Gonadotropin dosage. Timepoint: At the end of ovarian induction cycle. Method of measurement: Total number of ampoule.;Duration of ovarian induction. Timepoint: At the end of ovarian induction cycle. Method of measurement: Number of days.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoya Kabodmehri

Guilan University of Medical Scienses

royakabodmehri@yahoo.com+98 13 3336 9224

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 15, 2026