Vaginal versus intrauterine extra-amniotic misoprostol for inducing abortion in second trimester

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190606043830N1

Enrollment

112

Registered

2019-09-28

Start date

2019-06-18

Completion date

Unknown

Last updated

2019-11-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

second trimester missed abortion. Missed abortion

Interventions

Intervention 1: Intervention group: intrauterine extra-amniotic misoprostol administration. Intervention 2: Control group: vaginal misoprostol insertion.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: pregnant women at 13-24 weeks of gestational age two ultrasound report indicating non-visualization of Fetal heart rate

Exclusion criteria

Exclusion criteria: previous cesarean section hypersensitivity to misoprostol asthma adrenal disease amniotic membrane rupture placenta previa

Design outcomes

Primary

Measure	Time frame
The time needed for expulsion of products of gestation. Timepoint: every 30 minutes. Method of measurement: physical exam.	—

Secondary

Measure	Time frame
Hemoglobin level. Timepoint: at admission and 6 hours after expulsion. Method of measurement: Lab test.;Size of retained productions of conception after expulsion. Timepoint: 24 hours after expusion. Method of measurement: ultrasound assessment.;Adverse effects related to misoprostol. Timepoint: every 30 minutes. Method of measurement: physical examination and history taking.;Need to emergent surgery. Timepoint: every 30 minutes. Method of measurement: physical examination.	—

Measure

Time frame

Hemoglobin level. Timepoint: at admission and 6 hours after expulsion. Method of measurement: Lab test.;Size of retained productions of conception after expulsion. Timepoint: 24 hours after expusion. Method of measurement: ultrasound assessment.;Adverse effects related to misoprostol. Timepoint: every 30 minutes. Method of measurement: physical examination and history taking.;Need to emergent surgery. Timepoint: every 30 minutes. Method of measurement: physical examination.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNiloufar Beheshti Monfared

Iran University of Medical Sciences

nilou_beheshti@yahoo.com+98 21 5560 6034

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 13, 2026