Comparison of the effectiveness and complication of dexamethasone at doses of 8 and 24 mg in the treatment of in Hospitalized Patients with Covid-19

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20190606043826N2

Enrollment

Registered

2021-07-01

Start date

2021-07-06

Completion date

Unknown

Last updated

2021-07-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

covid 19 pneumonia. Multisystem inflammatory syndrome associated with COVID-19

Interventions

Intervention 1: Intervention group: Patients with covid 19 treated with dexamethasone 24 mg daily for 3 days and then 8 mg daily for 10 days or until discharge. Intervention 2: Control group: Patients

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Hospitalized Patients with Covid-19

Exclusion criteria

Exclusion criteria: Pregnancy Immunodeficiency diseases chronic liver and kidney diseases or gastrointestinal bleeding Glucocorticoid use in the last 1 month

Design outcomes

Primary

Measure	Time frame
Determination of mean arterial blood oxygen saturation with and without oxygen therapy. Timepoint: At the beginning of hospitalization and 3, 5, 7 and 10 days later. Method of measurement: pulse oxymeter.;Shortness of breath score based on modified Borg scale. Timepoint: At the beginning of hospitalization and 3, 5, 7 and 10 days later. Method of measurement: modified Borg scale.;Number of days required for mechanical ventilation. Timepoint: daily. Method of measurement: Counting days under mechanical ventilation.;Measurement of serum levels of C-reactive protein. Timepoint: At the beginning of hospitalization and 3, 5, 7 and 10 days later. Method of measurement: laboratory test.	—

Measure

Time frame

Determination of mean arterial blood oxygen saturation with and without oxygen therapy. Timepoint: At the beginning of hospitalization and 3, 5, 7 and 10 days later. Method of measurement: pulse oxymeter.;Shortness of breath score based on modified Borg scale. Timepoint: At the beginning of hospitalization and 3, 5, 7 and 10 days later. Method of measurement: modified Borg scale.;Number of days required for mechanical ventilation. Timepoint: daily. Method of measurement: Counting days under mechanical ventilation.;Measurement of serum levels of C-reactive protein. Timepoint: At the beginning of hospitalization and 3, 5, 7 and 10 days later. Method of measurement: laboratory test.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomayeh Sadeghi Haddad Zavareh

Esfahan University of Medical Sciences

S.sadeghi117917@gmail.com+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026